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Unraveling the Wonders of Polynucleotides: Nature's blueprint for life & what they can do for you.

Updated: Nov 16, 2023

Polynucleotides, are the latest and arguable the most advanced development in aesthetics in recent times. They are the fundamental building blocks of life and are the intricate molecules that form the backbone of every living organism. These remarkable macromolecules are composed of nucleotides, each comprising a sugar molecule (ribose in RNA or deoxyribose in DNA), a phosphate group, and a nitrogenous base. They serve as the genetic blueprints, directing the growth, development, and functioning of all living organisms.

Polynucleotides have revolutionised medicine, with applications ranging from gene therapies to personalised medicine. Their ability to target specific genes allows scientists to correct genetic defects and treat various diseases, promising transformative breakthroughs. So, how can we use them within the aesthetics industry I hear you ask?

In the aesthetics arena, polynucleotides have emerged as a cutting-edge tool to address infraorbital hollowing and promote skin rejuvenation. By harnessing their regenerative power, medical practitioners can stimulate collagen production and tissue repair like never before. Polynucleotides encourage the body's natural healing processes, leading to improved skin texture and tone. Additionally, these innovative treatments can be applied to achieve general skin rejuvenation, targeting fine lines, wrinkles, and other signs of ageing such as under eye hollows. By leveraging the remarkable properties of polynucleotides, patients can experience a more youthful and revitalised appearance, with long-lasting results and minimal side effects.

How do Polynucleotides Work? In layman's terms, polynucleotides are like an instruction manual telling our cells what to do. They are long chains made up of smaller building blocks called nucleotides. These nucleotides act like letters in a language, and their specific order forms words and sentences that our cells can read.

Polynucleotides have two main types: DNA and RNA. DNA holds all the genetic information that makes us unique and determines our traits, like eye colour or height. It stays inside the cell's nucleus, acting as the master blueprint for the entire body. When the cell needs to use the information from DNA to build something, it makes a copy of the relevant section of DNA into a temporary molecule called RNA. This process is like photocopying the important instructions from the master blueprint, so it can be taken out of the nucleus and used in the cell's "construction site."

Once outside the nucleus, the RNA tells the cell which proteins to make. Proteins are like the workers that carry out various tasks in our body, such as helping with digestion, repairing damaged tissues, or fighting off infections. So, the RNA guides the cell in assembling the necessary proteins, following the instructions encoded in the polynucleotide sequence.

In summary, polynucleotides work as the language of life, passing on information and guiding the cell in building the proteins needed for various functions in our body. They play a crucial role in determining our characteristics and ensuring our cells function correctly to keep us healthy and alive.

So, what can we use them to improve?

  • Restore skin elasticity

  • Imporve hollowing under the eyes

  • Heal sun-damaged skin

  • Improve photo-ageing (UV damage)

  • Improve scars

  • Restore hydration

  • Has Anti Inflammatory effect

  • Improves cell turnover (cell ageing)

  • Reduce hair thinning

How are polynucleotides administered in medical treatments, and what is the typical procedure like?

1. Injection: One of the most common and straightforward methods is through direct injection. Polynucleotides, often formulated as a solution, can be injected into specific tissues or areas of interest, such as the skin, joints, or muscles. Injections may be intramuscular, subcutaneous, or intra-articular, depending on the treatment goal. We often use this method for restoring lost volume in the infra-orbital region (under eye) and skin rejuvenation.

2. Topical Application: For certain skin-related therapies, polynucleotide formulations can be applied topically to the skin. This method is commonly used in aesthetic treatments for skin rejuvenation and hair restoration.

3. Electroporation: Electroporation is a technique that uses electrical pulses to temporarily create tiny pores in the cell membrane, allowing polynucleotides to enter the cells more effectively. This method is commonly used in gene therapy research and experimentation.

Whats the difference between Polynucleotides and skin boosters?


  • Polynucleotides, also known as PDRNs, are long-chain molecules composed of nucleotides (the building blocks of DNA and RNA). In aesthetics, polynucleotides are commonly used in treatments like skin rejuvenation and hair restoration.

  • When injected into the skin, polynucleotides work to stimulate collagen production and promote tissue regeneration.

  • They can improve skin texture, reduce fine lines and wrinkles, and enhance overall skin health.

  • Polynucleotides harness the body's natural regenerative processes, making them beneficial for anti-ageing and improving the skin's appearance. They can also be used for hair growth when applied to the scalp.

  • They are naturally occurring molecules

  • Long longevity of results

  • Minimal risks or negative side effects

  • Minimal to no downtimes after treatment

  • Less treatments per year compared to skin boosters

Skin Boosters:

  • Skin boosters are a type of dermal filler, in that they typically consist of hyaluronic acid, responsible for retaining moisture.

  • When injected into the skin, skin boosters attract and bind water molecules, effectively hydrating the skin.

  • They can help improve skin firmness and provide a radiant, youthful appearance.

  • Short longevity of results

  • More frequent, multiple treatments required in a year to maintain results.

Both treatments can be effective in addressing various aesthetic concerns, and the choice between them depends on the specific needs and goals of the individual. Consulting with a qualified aesthetic practitioner trained and experienced in both kinds of treatments is essential to determine the most suitable treatment plan for each person.

Are they safe?

Because polynucleotides are naturally occurring and within us they are generally considered to be safe, well tolerated and effective. They do not carry the risks of vascular occlusion (blocking off blood vessels) that dermal fillers can. And in the delicate under eye area they mitigate the risk of migration and tyndal effect which can so often occur with traditional fillers in this area.

The results...

We have been trying polynucleotides (quietly) in clinic with a very small number of patients so we can see and assess the results for ourselves. What we've seen so far has been excellant with the patients treated being very happy with their results.

A closer look of the patients' left under eye area. The top image (on the right) is before treatment the lower images is 5 months later.

Not only is the hollowing improved but also the discolouration/dark circles.

The top picture (on the left) is before treatment, the image underneath it is a full 12 months later. Which defiantly shows the under eye area still looking so much better than before.

So, now we've seen the results for ourselves we will officially be launching polynucleotides as a treatment in clinic.

As many of our patients are aware this is the only time we do any kind of offers.

The offer will go out via email to our existing patients and those on our mailing list first before general release for any remaining slots via on social media. We will have limited slots available at the introductory offer price and T&C's will apply so please read those carefully before booking an offer appointment.

Watch out for a specific 'offer' email which will be distributed in the next 2 weeks!

For all other appointments and bookings don't forget you can download our clinic app via either the app store or google play. Just search "Aluminate Clinic' and look for our logo!


Aluminate Clinic Team


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